Synthesis and characterization of PEGylated guar gum based nanoparticles: New approach in novel drug delivery system

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Abstract
Pharmacology, Toxicology and Biomedical Reports,2016,2,3,61-65.
Published:August 2016
Type:Original Article

Synthesis and characterization of PEGylated guar gum based nanoparticles: New approach in novel drug delivery system

Venugopal Vijayan1*, Munuswamy Purushothaman2, James Anbu Raj3

1Unit of pharmaceutical technology, Faculty of pharmacy, AIMST University, MALAYSIA.

2Department of Pharmaceutics, Vasavi institute of pharmaceutical sciences, Kadapa, Andhra Pradesh, INDIA.

3Department of Pharmaceutics, Arulmigu Kalasalingam College of Pharmacy, Srivilliputtur, Tamilnadu, INDIA.

Abstract:

Objective: To investigate the synthesis of guar gum PEGylation and the nanoparticles preparation and evaluation of drug release characters were studied. Methods: The PEGylated particle was prepared by emulsification with cold homogenization. Results: The Acyclovir loaded nanoparticles were uniform and spherical with smooth surface. The entrapment efficiency (EE %) was in range of 60-95%. The entrapment was increased with increase in concentration of PEGylated guar gum. The particle size of Acyclovir nanoparticle was in range between 234.8-879.6 nm with polydespersibility range of 0.006-0.024, which reveals monodisperse nature. The PEGylated nanoparticle showed sustained drug release at 24 hours in the range of 54.28-62.58%. The drug release behaviour was reported by zero order release with diffusion and erosion mechanism. Conclusion: The PEGylation was done successfully with guar gum. These PEGylated guar gum was produced spherical shaped nanoparticles and it was circulating and sustained the drug release in biocompatible manner. Acyclovir PEGylated nanoparticle was best choice for prolonged the drug release in HIV treatment.