In silico Screening of Thiazolidine 4-one Derivatives for Antitumor Activity

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Abstract
Pharmacology, Toxicology and Biomedical Reports,2017,3,2,35-38.
Published: October 2017
Type:Original Article

In silico Screening of Thiazolidine 4-one Derivatives for Antitumor Activity

Palayyan Muralidharan1*, Gejalakshmi Subramaniam2

1Department of Pharmacology, C.L.Baid Metha College of Pharmacy, Rajiv Gandhi Salai, Thoraipakkam,Tamil Nadu, INDIA.

2Faculty of Pharmacy, Dr. M.G.R. Educational and Research Institute, Chennai-600025, Tamil Nadu, INDIA.

Abstract:

Objectives: To evaluate the potent histone deacetylase inhibitory activity of thiazolidine 4-one derivatives using Molegro virtual docker 6.0 version. Methods: Chromone derivatives were drawn using ACD Chem Sketch software, Histone deacetylase a well-known tumor inhibitor is chosen as standard. Insilco docking studies were carried out using Molegro virtual docker version 6.0. Results: Docking results showed all the selected Ligands has binding energy ranging between 40.36 kcal/mol to-47.67kcal/ mol when compared with that of standard which has binding energy 40.42 Conclusion: Thiazolidone derivatives reported best histone deacetylase inhibitory activity because of its structural parameters. Further study on thiazolidine-4-one derivatives and in vivo and in vitro study are necessary to develop target moieties for treatment of tumor.