In vitro Antidiabetic Activity of Sulforaphane

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Abstract
Pharmacology, Toxicology and Biomedical Reports,2017,3,2,47-49.
Published:October 2017
Type:Short Communication

In vitro Antidiabetic Activity of Sulforaphane

Shaik Chand Basha1*, Komaragiri Rajesh Babu2, Medabalimi Madhu2, Chakka Gopinath1

1Department of Pharmaceutical Chemistry, Annamacharya College of Pharmacy, New Boyanapalli, Rajampet, Andhra Pradesh, INDIA.

2Department of Pharmaceutical Analysis, Annamacharya College of Pharmacy, New Boyanapalli, Rajampet, Andhra Pradesh, INDIA.

Abstract:

Background: Sulforaphane is mainly found in cruciferous vegetables. It is a glucosidal prodrug with many pharmacological activities like anti oxidant, anti ulcer, anti viral etc. The present work aims the screening of in vitro anti diabetic activity of Sulforaphane from broccoli extract. Method: The Hypoglycemic activity was performed with amylase inhibition assay by using chromogenic DNSA method. In this percentage inhibition of analyte was compared with that of control to conclude the proved anti diabetic activity. Result: Majority analyte concentration of 500μg exhibits significant inhibition of amylase enzyme which reflects potent anti diabetic effect. Conclusion: Despite of many adverse effects and short shelf life of present drugs here is a proved possibility of anti diabetic effect was found in Sulforaphane from broccoli extract.