Aphrodisiac Activity of Cocos Nucifera Attentuates Cerric Sulphate Induced Infertility in Male Rats

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Pharmacology, Toxicology and Biomedical Reports,2015,1,2,62-68.
Published:5th May, 2015
Type:Original Article

Aphrodisiac Activity of Cocos Nucifera Attentuates Cerric Sulphate Induced Infertility in Male Rats

Ramakrishnan Prakash*, Rajulu Dheeraj, Palayan Muralidharan, Krishnan Karthickeyan, Raji Vijayakumar and Thiraviam Purushoth Prabu

Department of Pharmacology, C.L. Baid Metha College of Pharmacy, Thorapakkam, Chennai-600097, INDIA.


Objective: In the present study, we examined the effect of hydroalcoholic extract of apical bud of cocos nucifera (HACN) in ceric sulphate induced infertility in male rats. Methods: Rats weighing 180 to 200 gm were randomized into 4 groups of 6 animals each that included saline treated rats (normal) were orally administered once daily with 0.5ml of distilled water, Ceric sulphate treated (1 mm/100 gm., s.c.) and HACN treated (200 and 400 mg/kg., p.o.). Ceric sulphate was given to the rats for 7 days for all the groups except saline treated rats then followed by administration of the HACN extract for 21 days. Parameters Evaluated: Sexual behavioural parameters including mount and intromission frequency (MF and IF) and mount, intromission and ejaculation latency (ML, IL, EL) as well as post ejaculatory interval (PEI) and body weight (BW) were recorded in male rats one hour after injection of extract by mating with a receptive female (1:1). Biochemical evaluation such as serum and cauda epididymidal testosterone and dihydrotestosterone (DHT) and histopathological analysis of testis were also assessed. Results: Ceric sulphate treated rats significantly decreased sexual behaviour and also reduced the serum and cauda epidymidal tissue testosterone and DHT when compared to control rats. All these changes were significantly attenuated by ceric sulphate rats (with HACN extract). Ceric sulphate was found to be inducing sterility in male rats which has been confirmed after analyzing all the parameters of the study. Conclusion: From the results it may be concluded that hydroalcoholic extract of cocos nucifera may be used as a good aphrodisiac activity which can promote the fertility rate.