@article {35, title = {Pre-Clinical Toxicological Evaluation of Rostellularia diffusa: Hematological, Biochemical, and Histopathological Studies}, journal = {Pharmacology, Toxicology and Biomedical Reports}, volume = {3}, year = {2017}, month = {September 2017}, pages = {66-69}, type = {Original Article}, chapter = {66}, abstract = {

Background:\ Rostellularia diffusa (Willd.) is a traditional herb belongs to acanthaceae family. The whole plants are used as brain tonic in traditional practice. There were no earlier reports on the safety assessment of Rostellularia diffusa. Objective: the present study was undertaken to assess the safe use of this plant in traditional practice. Method: The acute oral toxicity study of hydro alcoholic extract of Rostellularia diffusa (AERD) was carried out as per the OECD guidelines 423 and the sub-acute toxicity was carried out at a dose of 150 mg/kg and 300 mg/kg as per OECD 407 guidelines in male and female rats. Results: Rats were administered up to 2000 mg/kg as a single dose orally not caused any signs of toxicity or mortality in rats. In sub-acute toxicity study in rats, AERD at two different daily doses of 150 and 300 mg/kg for 14 days did not cause any significant change including the hematological and biochemical parameters. Histopathological examinations showed normal architecture suggesting no morphological disturbances. Conclusion: No deaths or any signs of toxicity was observed after oral administration in acute toxicity study up to a dose of 2000 mg/kg of AERD in rats and up to a dose of 300 mg/kg of AERD in sub-acute toxicity study in rats.

}, keywords = {Brain tonic, Herbal medicine, Rostellularia diffusa, Toxicity study}, doi = {10.5530/PTB.2017.3.13}, author = {Mohamed T S Saleem and Chinni Krishnaiah V and Gannepureddy Soumya and Sowjanya Burra and Shaik Abdul Hafeez and Repana Babu and Peddamoyana Rajesh Kumar and Gopinath Chakka} }