02326nas a2200217 4500008004100000024000700041245008700048210006900135260001800204300001000222490000600232520166200238653002701900653002501927653001801952653001201970653002201982100002002004700002002024856006402044 2023 eng d a0100aLevetiracetam-Induced Urination and Urinary Frequency in Pediatrics. A Case Report0 aLevetiracetamInduced Urination and Urinary Frequency in Pediatri cDecember 2023 a59-610 v93 a

Objectives: Levetiracetam (LEV) is a broad-spectrum antiepileptic drug used in children and adults. The use of LEV is associated with behavioral abnormalities as adverse drug reactions. However, it might increase the frequency of urination as an adverse effect, which has not been observed or reported previously in Saudi Arabia. It is a description of the unusual side effects of levetiracetam. Methodology: A case report of three patients aged 6, 5 and 6 years, respectively. They were diagnosed with epilepsy and treated with levetiracetam. After LEV treatment, all three cases experienced increased urinary frequency and incontinence. Results: The Naranjo Adverse Drug Reaction Probability Scale was applied on the three cases and was found to be possibly related in two cases to LEV therapy and probably related in one. We reduced the dose in one patient, and the side effects improved to half. Moreover, it was resolved after discontinuation of the medication. In the other two cases, the side effect resolved on its own. It was reported in the literature that 2 cases had urinary frequency after starting on levetiracetam and improved after reducing the dose and switching to other medication. Conclusion: LEV might induce an increase in the frequency of urination. It was an under-reported issue and should be addressed as a transient adverse drug reaction effect. However, it can strongly affect compliance with medication. Therefore, clinicians should be attentive and look exclusively for this symptom to educate the families during follow-up visits.

10aAdverse drug reaction.10aDaytime incontinence10aLevetiracetam10aUrgency10aUrinary frequency1 aBayounis, Manar1 aAl-Assadi, Nouf uhttp://www.ptbreports.org/article/2023/9/3/105530ptb2023910