01970nas a2200229 4500008004100000245010000041210006900141260001900210300001000229490000600239520123700245653003901482653001801521653001401539653000901553653002201562653000801584100002601592700002701618700003101645856006401676 2017 eng d00aDexamethasone-Loaded PLGA Microspheres: Effective and Sustained Anticancer Drug Delivery System0 aDexamethasoneLoaded PLGA Microspheres Effective and Sustained An cSeptember 2017 a55-610 v33 a

Objective: Encapsulation of dexamethasone (DEX) anticancer drug with Poly (d, l-lactide-co-glycolide) (PLGA) microsphere (MS) was carried out for sustained release system. Methods: The characterizations of MS were analyzed using XRD, FTIR, RP-HPLC, TEM, CLSM, and XRD patterns and reported the physical state of the encapsulated PLGA microsphere (DEXPLGA MS). Results: The presence of 2 θ peaks values at 33.17°, 35.63°, 49.46° and 54.09° confirmed the semi-crystalline phase for the DEX drug. FTIR showed peaks at 1695 cm−1, 1644 cm−1 and 1602 cm−1 were shown to be confirming DEX encapsulation. The MTT assay showed a greater cellular uptake of DEX-PLGA MS and the new formulation showed steady and sustained release of DEX resulting in a lower short term cytotoxic effect against HEP-G2 cells. Conclusion: In the present study, the drug encapsulation microsphere is non-toxic, simple, and an ideal method for anticancer drug release. The present results revealed that the use of DEX-PLGA MS offers large-scale production of biocompatible microspheres that can be used against HEP-G2 cells.

10aConfocal laser scanning microscopy10aDexamethasone10aMTT assay10aPLGA10aSustained release10aTEM1 aVimalkumar, Elangovan1 aKamaraj, Chinnaperumal1 aGandhi, Pachiyappan, Rajiv uhttp://www.ptbreports.org/article/2017/3/3/105530ptb2017311