02213nas a2200229   4500008004100000245003900041210003800080260001800118300001000136490000600146520154800152653001901700653002801719653001801747653002401765100002801789700003301817700003101850700002701881700002501908856005001933       2015                        eng d00aNew Age Antipsychotic: ILOPERIDONE0 aNew Age Antipsychotic ILOPERIDONE  c7th May, 2015  a41-490 v13 a<p class="rtejustify">Schizophreniais a heterogeneous, chronic, severe, and disabling brain disorder that has affected people throughout history. Schizophrenia is a severely debilitating psychiatric disorder observed worldwide, with a median lifetime prevalence of 0.7%–1.0%. Iloperidone possesses stronger affinity for serotonin (5- HT2A) than dopamine (D2) receptors, and its efficacy is roughly comparable to that of other (nonclozapine) antipsychotics. In May 2009, the Food and Drug Administration approved iloperidone for the acute treatment of schizophrenia in adults. Iloperidone may be a useful and safe option for the treatment of schizophrenia. Several confirmatory trials of iloperidone reported to reduced the symptoms of schizophrenia at oral doses from 12 to 24 mg, which was more effective than placebo in reducing positive and negative syndrome total score and Brief Psychiatric Rating scale scores. Iloperidone was found to be as effective as haloperidol and risperidone in post-hoc analysis. In several clinical studies, most common adverse events reported were dizziness, dry mouth, dyspepsia and somnolence, with few extra pyramidal symptoms and metabolic changes in short and long-term studies in adults. As per adverse effect concern, akathisia was rare in case of iloperidone but prolongation of the corrected QT (QTc) interval was comparable to haloperidol and ziprasidone. Further comparative studies are needed to assess the benefit/risk profile of iloperidone and its role in the treatment of schizophrenia.</p>
10aAntipsychotics10adopamine (D2) receptors10aSchizophrenia10aSerotonin (5-HT2A).1 aShah, Arpit, Navinchand1 aSejpal, Jaykumar, Jashvantra1 aKatwala, Jigar, Ravindrabh1 aJaiswal, Anil, Jagdish1 aKhan, Azadar, Husain  uhttps://www.ptbreports.org/article/2015/1/2-3